ABNORMALLY ELEVATED USP37 EXPRESSION IN BREAST CANCER STEM CELLS REGULATES STEMNESS, EPITHELIAL-MESENCHYMAL TRANSITION AND CISPLATIN SENSITIVITY

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity

Abstract Background Recent studies have indicated that deubiquitinating enzymes (DUBs) are related to the stem-cell pathway network and chemo-resistance in cancer.Ubiquitin-specific peptidase 37 (USP37), a novel DUB, was identified to be a potential factor associated with tumor progression.However, the biological functions of USP37 in breast cancer

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Phenomics and transcriptomics analyses reveal deposition of suberin and lignin in the short fiber cell walls produced from a wild cotton species and two mutants.

Fiber length is one of the major properties determining the quality and commercial value of cotton.To understand the mechanisms regulating fiber length, genetic variations of cotton species and mutants producing short fibers have been compared with cultivated cottons generating long and normal fibers.However, their phenomic variation other than fib

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Das Problem der verschwiegenen Arisierung jüdischen Eigentums in der zeitgeschichtlichen KJL – Zu Mirjam Presslers Jugendroman "Die Zeit der schlafenden Hunde" (2003)

Expropriation of Jewish property in the Nazi era and dealing with criminal history of the family by its descendants constitute the pivot of the young-adult novel "Die Zeit der schlafenden Hunde" (Let Sleeping Dogs Lie) by Mirjam Pressler.A confrontation Supplies with a Jewish victim of the expropriation induces the adolescent protagonist to expose

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Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice

Abstract Reward and motivation deficits are prominent symptoms in many mood disorders, including depression.Similar reward and effort-related choice behavioral tasks can be used to study aspects of motivation in both rodents and humans.Chronic stress can precipitate mood disorders in humans and maladaptive reward and motivation behaviors in Model P

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